David A. Sinclair is a biologist best known for his research on the biology of lifespan extension and driving research towards treating diseases of aging. He is an Associate Professor of Pathology and Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard Medical School. Dr. Sinclair obtained a Bachelors of Science (Summa Cum Laude) at the University of New South Wales, Sydney, and received the Australian Commonwealth Prize. In 1995, he received a Ph.D. in Molecular Genetics then worked as a postdoctoral researcher at M.I.T. with Leonard Guarente before being recruited in 1999 to Harvard Medical School.
Dr. Sinclair has received several additional awards including a Helen Hay Whitney Postdoctoral Award, and a Special Fellowship from the Leukemia Society, a Ludwig Scholarship, a Harvard-Armenise Fellowship, an American Association for Aging Research Fellowship, and a Scholarship from the Ellison Medical Foundation. In 2003, one of his papers was considered a "Discovery of the Year" by Discover magazine. In 2004, he won the Genzyme Outstanding Achievement in Biomedical Science Award. In 2006 he was voted one of Australia's Top 10 scientists under 45, and co-authored the cover article of the March '06 issue of Scientific American. In 2004, Dr. Sinclair co-founded Sirtris Pharmaceuticals to develop drugs that harness the body's own defenses against diseases of aging, which was featured on the cover of Fortune magazine in Jan 2007. archive/2007/02/05/8399158/index.htm" target="_blank">http://money.cnn.com/magazines/fortune/fortune_archive/2007/02/05/8399158/index.htm
One of Sinclair's most important discoveries was that the elucidation of the key role of rDNA circles in determining the lifespan of yeast, which at the time received much media attention. As it turned out, this rDNA circle mechanism of aging is unique to a particular strain of yeast and not observed either in other inverterates or mammals. In a more recent study by Sinclair, published in November 2006 by the journal _Nature indicated that resveratrol had life-extending activity in mice fed an extremely high fat diet (60% fat). Preliminary results showed that these obese mice lived considerably shorted than normally fed mice, and that obese mice treated with resveratrol lived an average of 15% longer than obese mice not provided the supplement. Though the question of whether normally fed mice also show lifespan extension by resveratrol remained unanswered in that study.
In 2006, David was awarded the Telluride Tech Festival Award of Technology in Telluride, Colorado.
Despite widespread media attention, Sinclair and his work remain controversial, as attested by frequent argumentative exchanges in the scientifc literature with former colleagues.
David Sinclair (born October 6, 1969 in Dunfermline) is a Scottish former footballer who played in defence.
David Sinclair (portrayed by Alimi Ballard) is a promising FBI agent in the TV show Numb3rs. Since Season 2, David is usually partnered with Colby Granger and tried to stick up for him in "The Mole." In fact, in the Season 3 finale, "The Janus List", when Colby is revealed to be a double agent working as a spy for the Chinese, David reacted with deep pain and blind fury at the betrayal, tears welling in his eyes during Colby's confession just before he attempted to assault Colby in the interrogation room of the L.A. office. Even with the possibility of Colby having been a triple agent and the will to save him, David is not ready to see his partner yet, as he feels he doesn't really know him. Alan has given him something to think about, as Mr. Eppes had said this is a test of true friendship and that he must try to understand his motives. The two are close once more, but only after many failures to cooperate on a mission.
David was assigned to work with Don Eppes in the pilot episode, by the assistant director. By Season 3, he has been with Don three years, and there's nothing Don can't ask David to do. Though, Don worries David may one day realize he's seen too much and leave the FBI. He has knowledge of defusing explosive devices due to his first posting overseas in Tel Aviv, Israel. In addition, David did some work for the Long Beach FBI office.
David carries a Glock 22 pistol.
David's two best friends in childhood were Ben Ellis and Earl Day, as revealed in the episode "Contenders." He grew up in the Bronx, and has mentioned growing up dodging gangs to get an education. He currently lives in Venice, California. Sinclair enjoys Alan's cooking and he is infatuated with medical examiner Claudia Gomez (Lauren Vélez).
