Cybersix is a series of Argentine comic books created by writers Carlos Meglia and Carlos Trillo. The series first appeared in Spanish in November, 1993.

The heroine of the series is the eponymous character, Cybersix, a leather-clad artificial human superhero who by day operates behind the guise of a male high school literature teacher, and by night battles the monstrous biological weapons of her creator. She is aided in her adventures by her younger brother Cyber-29, who is reborn in the body of a black panther known as Data 7. The extended cast includes Cybersix's colleague and love interest Lucas Amato, as well as other supporting characters.

In 1995, the comics were adapted into a poorly-received live-action television series, and again in 1999 into a much more successful thirteen-episode animated series by TMS, with positive critical reception from sources like the Pulcinella Awards, which first aired in Canada on Teletoon and was later dubbed in several other countries.

Cybersix is the name of a powerful advanced female genetic construct android who is the creation of malevolent scientist named Von Richter. He considers her a failed creation owing to her indomitable free will and she was forced to escape to avoid termination by her creator. Now she hides in regular society as a male teacher named Adrienne Seideleman, but she stalks the night as a caped superhero. Vowing eternal opposition to the plans of her creator and his henchmen, she protects her new found world and friend and seeks the humanity that her creator denied from her. Written by Kenneth Chisholm

Cybersix is the name of genetically created female made by the malicious Dr.Von Reichter. She is one of many individuals in the "Cyber-series" who are all ultimately terminated because of their innate humanity and sense of good. However, before she can be destroyed, she escapes from Von Reichter and hides in regular society disguised as a male high school teacher, Adrian Seidelman. She eventually teams up with "Data 7", another of Von Reichter's creations. Data 7 is, in fact, her brother Cyber 29, who was killed in an accident and had his consciousness transplanted into a panther. Together, they work to thwart the plans of Von Reichter, his son Jose and their genetic mutation army. Throughout, Cybersix tries to maintain her secret identity from her close friend and co-worker, Lucas Amato. As well, she constantly debates her existence and what it all means, since she knows full well that she is not actually human, but a genetic creation. Written by Matthew Wong