Cocaine (Methylbenzoylecgonine) is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine. It is both a stimulant of the central nervous system and an appetite suppressant. Specifically, it is a dopamine reuptake inhibitor. Because of the way it affects the mesolimbic reward pathway, cocaine is addictive. Nevertheless, cocaine is used in medicine as a topical anesthetic, even in children, specifically in eye, nose and throat surgery.

Its possession, cultivation, and distribution are illegal for non-medicinal and non-government sanctioned purposes in virtually all parts of the world. Although its free commercialization is illegal and has been severely penalized in virtually all countries, its use worldwide remains widespread in many social, cultural, and personal settings.

Cocaine is a song written by Oklahoma singer-songwriter J. J. Cale, and most notably covered by Eric Clapton on his 1977 album Slowhand.

Cale had written this song early in his career as a jazz piece. It was later recommended that he record a rock version, which he did; it was released on his fourth album, Troubadour. When the album was first released, radio stations refused to play "Cocaine," for obvious reasons. Considering his limited fame, Cale was very easy to say no to at the time, but when Eric Clapton recorded it a year later, stations started to play it.