Chandramukhi (Tamil: சந்திரமுகி) is a 2005 Indian musical, horror, comedy directed by P. Vasu and produced by Ramkumar Ganesan of Sivaji Productions. It is the remake of the Kannada language film, Apthamitra, which itself was based upon a Malayalam film, Manichitrathazhu. The music for the film, which later became successful enough to be released as a soundtrack album, was written by Vidyasagar. It is the remake of the Award winning malayalam movie "Manichitrathazhu".

This Rajinikanth film had a large cast. Jyothika Saravanan, Prabhu Ganesan, Nayanthara, Vineeth, and Malavika were also given lead roles while Vadivelu, Nassar, and Vijayakumar had important roles as well. It was released on the eve of the Tamil New Year, April 14, 2005 to become the largest opening in Tamil cinema at the time. It was subsequently dubbed into Telugu and released on December 29, 2005 with the same title. On February 29th, 2008, Producer M.Rathnam had dubbed and released the film in Hindi, despite Bhool Bhulaiyaa being released in the past.

Since release, Chandramukhi has become the highest grossing Tamil language film ever beating the previous record set by Rajinikanth's previous film, Padayappa. The film also became the longest ever running South Indian film, completing 800 days at Shanthi Theatres in Chennai on June 25, 2007 passing the record of the 1935-devotional film, Haridas. It was also the first Tamil movie to be dubbed into German and released in German-speaking nations.

Senthil (Prabhu) and Ganga (Jyothika) marry against the wishes of their extended family, and move into a mansion right next to where the cousin intended as Senthil's bride Shweta (Malavika) lives. Several members of Shweta's family are miffed at Senthil's "unauthorized" wedding, and his mother start's fearing for the newlyweds' safety when they move next-doors to their cousins. Soon after moving into their new house, strange things start happening, whether these are caused by the apparent ghost of a former occupant, Chandramukhi, or any one of the suspicious members of the extended family, will be looked into by "psychiatrist extraordinaire" Dr. Sarvanan (Rajnikanth). Very entertaining, especially if you enjoy Rajnikanth's films. Notice here the trademark Rajni cigarette flip is substituted by the more politically correct chewing gum. Remake of Manachitratazhu. Written by Joyojeet Pal