Caroline Reynolds is a fictional character from the American television series Prison Break, played by Patricia Wettig. She is a recurring character introduced in the second episode of the series as a mysterious woman (often seen performing culinary work) whose face was not shown until the eighth episode of the series, where she was revealed to be the Vice President of the United States. Her brother, Terrence Steadman, is the man whom Lincoln Burrows was convicted of killing. Reynolds thus becomes more prominent, becoming the main antagonist of the first season.

In the first season, Reynolds is affiliated with a covert organization known as "The Company" with whom she shares the same goal - to make sure that Lincoln Burrows is executed for her brother's "murder." Due to Patricia Wettig's commitment to another television series, Brothers & Sisters, the character's first appearance in the second season was in the nineteenth episode, "Sweet Caroline," for which Wettig was credited as a "Special Guest Star." Despite Reynolds's extended absence prior to this episode, the plot continued to develop around her, and Wettig provided voiceovers for the second season episodes "The Message" and "Chicago".