Buffalo ( ), is an American city in western New York. It lies at the eastern end of Lake Erie and the southern head of the Niagara River.

As of the 2000 census, the city had a total population of 292,648. Buffalo is the state's second-largest city after New York City and is the county seat of Erie County.

Buffalo is the economic and cultural center of the Buffalo-Niagara Falls metropolitan area, an area with a population of 1.2 million people. Buffalo is the largest city of both the Buffalo Niagara Region and of Western New York.