Boa vs. Python is a 2004 Sci Fi Pictures original film. It was directed by David Flores, from a script by Chase Parker and Sam Wells, and was filmed in Sofia, Bulgaria. It is technically not a sequel to the Python series of movies, but the incidents in the Python movie series are mentioned by Agent Sharpe.

After an overly ambitious businessman transports an 80-foot python to the United States, the beast escapes and starts to leave behind a trail of human victims. An FBI agent and a snake specialist come up with a plot to combat the creature by pitting it against a bioengineered, 70-foot boa constrictor. It's two great snakes that snake great together! Written by SciFi