"Astronomy Domine" is a song by British Psychedelic rock band Pink Floyd. The song, written and composed by original vocalist/guitarist Roger 'Syd' Barrett, was the first track featured on their debut album, The Piper at the Gates of Dawn (1967). The lead vocal was sung by Barrett and keyboard player Richard Wright.

"Domine" (meaning "Lord") in the title is correctly pronounced as it is in Latin ([ˈdɒmɪneɪ], rather than [dəʊˈmiːn] or [dəʊˈmaɪn]).