Arsenic and Old Lace is a film directed by Frank Capra based on a play by the same name by Joseph Kesselring. The script was adapted by Julius J. Epstein. Capra actually filmed the movie in 1941 but it was not released until 1944 while the studio waited for the stage version to finish its run on Broadway. The lead role of Mortimer Brewster was originally intended for Bob Hope, but he couldn't be released from his contract with Paramount. Capra had also approached Jack Benny and Ronald Reagan before settling on Cary Grant. Boris Karloff played Jonathan Brewster on the stage, while in the movie Raymond Massey plays Jonathan, who "looks like Karloff". If not for the stage play, Karloff would have played the same role in the film.

In addition to Grant as Mortimer Brewster, the film also starred Josephine Hull and Jean Adair as the Brewster sisters, Abby and Martha, respectively. Hull and Adair as well as John Alexander (who played Teddy) reprised their roles from the original 1941 stage production.

Mortimer Bruster is a newspaperman and author known for his diatribes against marriage. We watch him being married at city hall in the opening scene. Now all that is required is a quick trip home to tell Mortimer's two maiden aunts. While trying to break the news, he finds out his aunts' hobby; killing lonely old men and burying them in the cellar. It gets worse. Written by John Vogel

The year is 1941. The location is a small house next to a cemetery in Brooklyn. In this house live two kind, thoughtful, sweet old ladies, Martha and Abby Brewster who have developed a very bad habit. It appears that they murder lonely old men who have some sort of religious affiliation and they consider doing it a charity. They then leave it to their bugle blowing nephew Teddy (who thinks he's Teddy Roosevelt) to take them to the Panama Canal (the cellar) and bury them. In this instance, the "poor fellow" suffers from yellow fever found in the window seat. It is another of their nephews Mortimer Brewster, a dramatic critic, who returns home only to find the man in the seat by mistake. Another nephew, Jonathon, returns to the home after years of fleeing the authorities due to his "unofficial practice" of killing people and using their faces to change his. However the results cause him to look like Boris Karloff (this angers him upon the mention of his similarity to the actor) due to the poor craftsmanship of his German accented, alcoholic sidekick Dr. Einstein. As the story continues, we see each character trying to find resolve in their suddenly been flipped upside-down lives. Mortimer tries to keep his aunts safe and prevent them from continuing their nasty habit while trying to stay sane with the woman he loves (Elaine Harper), the aunts try to continue their "charities", and Jonathon tries to make a wealthy practice that is stationed inside the home. Written by Andrew G. Wallace -- Mortimer Brewster -- Bergen Community College Theater Production, 2003