The Antarctic Peninsula is the northernmost part of the mainland of Antarctica, and almost the only part of that continent that extends outside the Antarctic Circle. It lies in the Western Hemisphere, facing South America, making it a part of West Antarctica. It extends from a line between Cape Adams (Weddell Sea) and a point on the mainland south of Eklund Islands, to Prime Head (63º13'S). The peninsula forms part of the British Antarctic Territory.

The first sighting of Antarctic Peninsula is contested but apparently occurred in the 1820s. Agreement on this name by the US-ACAN and UK-APC in 1964 resolved a long-standing difference over the use of the American name "Palmer Peninsula" or the British name "Graham Land" for this feature. (Graham Land is now that part of the Antarctic Peninsula northward of a line between Cape Jeremy and Cape Agassiz, whilst Palmer Land is the part southward of that line. Palmer Land is named for the American seal hunter, Nathaniel Palmer.) In Chile, the peninsula is officially referred as O'Higgins Land, after the Chilean patriot and Antarctic visionary. Other Spanish countries call it "Península Antártica", among them Argentina (while also calling it "Tierra de San Martín"), which has more bases and personnel there than any other nation.

The peninsula is highly mountainous, its highest peaks rising to approximately 2,800 metres (9,186 feet). These mountains are considered to be a continuation of the Andes of South America, with a submarine spine connecting the two. That is an argument advanced by Chile and Argentina for their territorial claims. The peninsula has a sharp elevation gradient, with glaciers flowing into the Larsen Ice Shelf, which experienced significant breakup in 2002.

Since the peninsula has the mildest climate in Antarctica, the highest concentration of research stations on the continent can be found there, or on the many nearby islands, and is the part of Antarctica most often visited by tour vessels and yachts.

Hope Bay, at , is near to the northernmost extremity of the peninsula, which is Prime Head, at 63º13'S.