Annie Potts (born October 28, 1952) is an American television and film actress.

She is probably best known for playing the role of Janine Melnitz in the Ghostbusters films and for the television sitcom Designing Women, but has had a wide variety of prominent roles in both television and film. Other notable roles include Mary Elizabeth (O'Brien) Sims on the Lifetime Television show Any Day Now, the voice of Little Bo Peep in the Toy Story films, a supporting role in the John Hughes drama Pretty in Pink, and a recent guest-starring role on the CBS drama Joan of Arcadia.

She has done work on audio books, including as the narrator and heroine of Larry McMurtry's "Telegraph Days." She starred in the film version of McMurtry's Texasville, a sequel to The Last Picture Show.

Annie Potts is the daughter of Powell Grisette Potts and Dorothy Harris (Billingslea) Potts and has two older sisters, Mary Eleanor (Potts) Hovious, and Elizabeth Grissette ("Dollie") Potts. She was born in Nashville, Tennessee, and grew up in Franklin, Kentucky, where she graduated from Franklin-Simpson High School. She received a Bachelor in Fine Arts degree (in theater arts) from Stephens College in Missouri. When Potts was 17, she was hit by a car driven by a man under the influence of alcohol.

Potts is married to television director James Hayman and is the mother of three sons, Clay (born 1981), James (called Doc, born 1992), and Harry (born 1996). She is a dedicated Board Member of Stephens College, and has been instrumental in fundraising efforts for the college for many years. Potts is currently a visiting professor of Drama at the school.

Interested in stage and film at an early age, Annie Potts attended Stephens College in Missouri, enrolling in the theater studies course, followed by graduate work in California. At the age of 20 she married her college sweetheart, Steven Hartley. Only a short time later she and her husband were in a serious automobile accident in New Mexico - their Volkswagen bus was demolished by two drivers who were drag racing. Steve lost a leg, and Annie had multiple fractures (resulting in a traumatic arthritis that still persists). Early roles were primarily in television, such as Black Market Baby (1977) (TV), but her presence moved up with an appearance in the mega-hit Ghost Busters (1984) and then she hit the big time with a seven-year stint as one of the stars of "Designing Women" (1986). A brief period in "Love & War" (1992) ended with the cancellation of the show, about which she remains resentful.