Andrew J. Lederer appeared as a vocal soloist with the Brooklyn Borough-Wide Chorus, both in live performance and on CBS-TV. He became a comedian as a teenager and acted in movies and television, including Family Ties, The Facts of Life, and Fame plus starring roles in the movies Out of Control and Body Count (and an excised scene - later restored on DVD - in This is Spinal Tap). Later, he became an entertainment journalist, working as a writer and/or editor for Film Threat Magazine, Wild Cartoon Kingdom, Sci-Fi Universe and others (even the National Enquirer!).

Andrew wrote a substantial portion of the famous Disney/McDonalds Trivia Challenge (which was so hard it was reported on in the major newsweeklies and caused the overworked library of the Academy of Motion Picture Arts and Sciences to suspend its information line for the duration of the contest). His original screenplay,Won't Fade Out, was given its own chapter in the book The 50 Greatest Movies Never Made (St. Martin’s Press, 1999), alongside unfinished efforts by the likes of Stanley Kubrick, Billy Wilder, and Alfred Hitchcock.

With Dave Feinman, Andrew created CWA, a semi-cooperative management company that represented many of the better Los Angeles comedians for acting work during the late 1990s.

Andrew is a prominent “alternative” comedian. His long-running The Second Show and Eugene Mirman and Bobby Tisdale's Invite Them Up were the first comedy shows at Rififi/Cinema Classics, one of alternative or indie comedy's most important New York venues. His one-person shows, Petula Clark's Greatest Hits, Bridge-Burner, and Me and Hitler were all presented as part of the Edinburgh Fringe Festival. In 2007, Andrew as a consultant for a new Fringe venue, The Green Room. He recently made a high profile return to singing as part of the Loser's Lounge Tribute to the Bee Gees. He has a daily blog on the UK's Chortle comedy website.