The American Museum of Science and Energy (AMSE) is a science museum in Oak Ridge, Tennessee, designed to teach both children and adults about energy, especially nuclear power. The museum began in 1949 in an old wartime cafeteria and moved to its current location in 1975. The museum was originally named the American Museum of Atomic Energy but that name was changed in 1978.

The museum has both permanent and rotating exhibits, including robots, science puzzles, a NOAA weather station, a timeline of atomic discoveries, a large Van de Graaff generator, and a solar demonstration project.

The museum is open seven days a week. The museum was free to the public for many years, but admission is currently six dollars for students and senior citizens, and eight dollars for adults.