America's Next Top Model, Cycle 6 premiered on March 8, 2006, which would be the last cycle to air on UPN before merging with the The WB to create the The CW. The catch-phrase for this cycle was "Fairy Tales Come True".

The international destination during this cycle was Bangkok, Thailand. The winner was 20 year old Danielle Evans from Little Rock, Arkansas, who won a photo shoot for Elle magazine, a contract for representation with Ford Models, and a $100,000 contract with CoverGirl cosmetics.