The .223 Remington is a sporting cartridge with the same external dimensions as the 5.56x45mm NATO military cartridge. It is loaded with a 0.224-inch diameter, jacketed bullet, with weights ranging from 40 up to 90 grains, though the most common loadings by far are 55 grains.

The primary difference between .223 Remington and 5.56x45mm is that .223 is loaded to lower pressures and velocities compared to 5.56 mm. .223 Remington ammunition can be safely fired in a 5.56 mm chambered gun, but the reverse can be an unsafe combination. The additional pressure created by 5.56 mm ammo will frequently cause over-pressure problems such as difficult extraction, flowing brass, or popped primers, but in extreme cases, could damage or destroy the rifle. Chambers cut to .223 Remington specifications have a shorter leade (throat) area as well as slightly shorter headspace dimensions compared to 5.56 mm "military" chamber specs, which contributes to the pressure issues.